生物医药研究院

孙京川

生物医药研究院

研究副教授

sunjc@mail.sustc.edu.cn


教育经历

2006年5月     Texas A&M University     博士


工作经历

2018.3 - 今           南方科技大学     研究副教授

2016.11–2018.3   电子显微镜资源实验室在宾夕法尼亚大学, 管理冷冻电子显微镜

2016.8–2016.11   VARI 学院, 科学家。

2008.7–2016.8     生物科学系, Brookhaven 国家实验室,  研究助理. 冷冻电子显微镜。

2006.6–2008.7     lineberger 癌症中心, 北卡罗来纳大学教堂山, 博士后研究员, DNA 和蛋白质复合体的电子显微镜。


交叉研究领域

使用冷冻电镜研究生物大分子结构, 包括有关DNA复制的蛋白复合体,膜蛋白(信号传递受体,离子通道)。


所获荣誉

荣获Brookhave国家实验室2012 Spotlight 奖


代表文章

1. Sun J, Yuan Z, Bai L, Li H. (2016) CryoEM of dynamic protein complexes in eukaryotic DNA replication. Protein Sci. Sep 2. Review. PMID: 27589669

2. Sun J, Yuan Z, Georgescu R, Li H, O’Donnell ME. (2016) The Eukaryotic DMG helicase pumpjack and integration into the replisome. Nucleus. 7(2):146-54.

3. Yuan Z, Bai L, Sun J, Georgescu R, Liu J, O’Donnell ME, Li H. (2016) Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat Struct Mol Biol. 23(3):217-24.

4. Eswaramoorthy S, Sun J,  Li H, Singh BR, Swaminathan S. (2015) Molecular Assembly of Clostridium botulinum progenitor M complex of type E. Scientific Reports 5:17795

5. Sun J, Shi Y, Georgescu RE, Yuan Z, Zhait BT, Li H, O’Donnell ME. (2015) The architecture of a eukaryotic replisome. Nat Struct Mol Biol. 3113

6. Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M. (2015) Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication. Elife. 05795

7. Sun J, Fernandez-cid A, Riera A, Stillman B, Speck C, Li H. (2014) Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function. Genes Dev. 28(30):2291-303 

8. Sun J, Evrin C, Samel S, Fernandez-cid A, Riera A, Kawakami H, Stillman B, Speck C, Li H. (2013) Cryo-EM structure of  a helicase loading intermediate containing ORC-Cdc6-Cdt1-Mcm2-7 bound to DNA. Nat Struct Mol Biol. 20(8):944-51.

9. Sun J, Kawakami H, Zech J, Speck C, Stillman B, Li H. (2012). Cdc6-Induced Conformational Changes in ORC Bound to Origin DNA Revealed by Cryo-Electron Microscopy. Structure. 7;20(3):534-44.

10. Sun J, Li H. (2010). How to operate a cryo-electron microscope. Methods Enzymol. 481:231-49.

11. Raschle,M., Knipsheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D., and Walter, J.C. (2008). Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134(6), 969-980.

12. Sun, J., DuFort, C., Daniel, MC., Murali, A., Chen, c., gopinath, K., Stein, B., De, M., Rotello, VM., Holzenburg, A., Kao, CC. and Dragnea, B. (2006). Core-controlled polymorphism in virus-like particles. Proc. Natl. Acad. Sci. USA. 104, 1354-1359

13. Sun, J., Duffy, K., Xiong. J., Ranjith-Kumar, C.T., Masarapu, H., Lamb, R., Santos, J., Cunningham, M., Holzenburg, A., Sarisky, R.T., Mbow, M.L., and Kao, C. (2006). Structural and functional analyses of the human toll-like receptor. J. Biol. Chem. 281, 11144-11151.

14. Sun, J., Savva., C.G., Deaton., J., Kaback., H.R., Svrakic., M., Young. R., and Holzenburg., A. (2005). Asymmetric binding of membrane proteins of GroEL. Arch. Biochem. Biophys. 434, 352-357. (Journal Cover) 

                                               

联系方式

sunjc@mail.sustc.edu.cn

13902951605