生物医药研究院

谢兴巧

生物医药研究院

研究助理教授

xiexq@sustc.edu.cn


教育经历

2010-2013      南开大学    生物化学与分子生物学    博士

2007–2010     南开大学    生物化学与分子生物学    硕士

2003–2007     赣南师范学院    生物科学    学士


工作经历

2017-至今    南方科技大学    前沿与交叉研究院    助理研究教授

2015-2017     南方科技大学    生物系     博士后

2013-2015    中科院上海有机化学研究所    博士后


交叉研究领域

交叉研究领域涉及结构生物学,神经科学,以及基于质谱分析的蛋白质组学。利用蛋白质组学的方法,鉴定与突触形成相关的蛋白相互作用网络及蛋白质机器。通过结构生物学的方法,解析这些新型蛋白质机器的三维结构。在神经系统中,研究蛋白结构与功能的关系。探究神经发育及相关疾病的分子机制。


所获荣誉

博士研究生国家奖学金 


代表文章

1. Xingqiao Xie#, Faxiang Li #, Yuanyuan Wang, Yingli Wang, Zhijie Lin, Xiaofang Cheng, Jianping Liu, Changbin Chen, Lifeng Pan,Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2, Autophagy, 2015, 11(10):1775-1789

2. Xingqiao Xie#, Xiaojie Yan#, Zheng Wang, Hao Zhou, Wentao Diao, Weihong Zhou, Jiafu Long, Yuequan Shen, Open-closed motion of Mint2 regulates APP metabolism, J Mol Cell Biol, 2013, 5(1): 48-56

3. Xue Yang#, Xingqiao Xie#, Liu Chen, HaoZhou, Zheng Wang, Weijing Zhao,  Ran Tian, Rongguang Zhang, Changlin Tian, Jiafu Long, Yuequan Shen, Structural basis for tandem L27 domain-mediated polymerization, The FASEB Journal, 2010, 24(12):4806-4815

4. Faxiang Li, Xingqiao Xie, Yingli Wang, Jianping Liu, Xiaofang Cheng, Yujiao Guo, Yukang Gong, Shichen Hu, Lifeng Pan, Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins,Nature Communications, 2016, 13;7:12708.

5. Huisha Xu, Zhijie Lin, Fengzhi Li, Wentao Diao, Chunming Dong, Hao Zhou, Xingqiao Xie, Zheng Wang, Yuequan Shen, Jiafu Long, Dimerization of elongator protein 1 is essential for Elongator complex assembly, Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(34):10697-10702

6. Xinlei Chu, Xiaohong Qin, Huisha Xu, Lei Li, Zheng Wang, Fengzhi Li, Xingqiao Xie, Hao Zhou,Yuequan Shen, Jiafu Long, Structural insights into Paf1 complex assembly and histone binding, Nucleic Acids Research, 2013, 41(22): 10619-10629

7. Zhijie Lin, Weijing Zhao, Wentao Diao, Xingqiao Xie, Zheng Wang,Jinxiu Zhang, Yuequan Shen, Jiafu Long, Crystal structure of elongator subcomplex Elp4-6, Journal of Biological Chemistry, 2012, 287(25): 21501-21508

8. Jinxiu Zhang, Xue Yang, Zheng Wang, Hao Zhou, Xingqiao Xie, Yuequan Shen, Jiafu Long, Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode.,Journal of Biological Chemistry, 2012, 287(14):11132-11140

9. Xinghai Liu, Peiquan Chen, Baolei Wang, Weili Dong, Yonghong Li, Xingqiao Xie, Zhengming Li, High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors, Chemical Biology & DrugDesign, 2010, 75(2):228-232

10. Xiaojie Yan, Hao Zhou, Jinxiu Zhang, Chaowei Shi, Xingqiao Xie, Yinan Wu, Changlin Tian, Yuequan Shen, Jiafu Long, Molecular Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax-Interacting Protein-1, Journal of Molecular Biology, 2009, 392(4):967-976


联系方式

xiexq@sustc.edu.cn

13671959351