生物医药研究院

宁澄清

生物医药研究院

研究助理教授

ningcq@sustc.edu.cn


教育经历

2011-2015 中南大学,药物化学,医学博士

2008-2011 中南大学,药物化学,医学硕士

2004-2008 江西中医学院,药学,理学学士


工作经历

2018-至今 南方科技大学,研究助理教授

2015-2017 南方科技大学,博士后


交叉研究领域

研究方向主要为小分子药物的设计、合成与活性研究,研究内容主要包括运用计算机辅助药物设计、有机合成及高通量活性筛选等技术手段来进行抗肿瘤先导物和炎症抑制剂的开发,探索其用于癌症以及阿尔茨海默症等神经退行性疾病治疗的可能。


代表文章

1. Chengqing Ning, Liumei Mo, Xuwei Chen, Wentong Tu, Jun Wu*, Shengtao Hou*, Jing Xu*. Triptolide derivatives as potential multifunctional anti-Alzheimer agents: Synthesis and structure–activity relationship studies, Bioorganic & Medicinal Chemistry Letters, 2018, 28(4): 689-693.

2. Wentong Tu, Chengqing Ning*, Jing Xu*. Enantioselective synthesis of (-)-phaseic acid, Organic Chemistry Frontiers, 2018, 5(1): 29-31.

3. Chengqing Ning, Cheng Lu, Liang Hu, Yanjing Bi, Lei Yao, Yujun He, Lifei Liu, Xiaoyu Liu*, Niefang Yu*. Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2. European Journal of Medicinal Chemistry. 2015, 95, 104-115.

4. Chengqing Ning, Yanjing Bi, Yujun He, Wenyuan Huang, Lifei Liu, Yi Li, Sihan Zhang, Xiaoyu Liu, Niefang Yu*. Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2013, 23, 6432–6435.

5. Chengqing Ning,Wenyuan Huang, Wen Wu, Cheng Lu, Yujun He, Lei Yao, Lifei Liu, Xiaohe Zhen, Xiaoyu Liu*, Niefang Yu*. Discovery of novel potent HDAC inhibitors by structure-based optimization of cinnamic hydroxamic scaffold. Letters in Drug Design & Discovery. 2015, 12, 344-350.


联系方式 

0755-88018396

ningcq@sustc.edu.cn