生物医药研究院

谢启荣

生物医药研究院

研究副教授

xieqr@sustc.edu.cn


教育经历

2007    香港城市大学,生物及化学系,博士

2002    香港城市大学,生物及化学系,硕士

1999    香港城市大学,生物及化学系,学士(一等荣誉)


工作经历    

2017/12-今    南方科技大学,前沿与交叉科学研究院,研究副教授

2017/04–2017/10    香港浸会大学,中医药学院,研究学者

2012/08–2017/09    香港浸会大学深圳研究院,副研究员

2012/04–2017/03    香港浸会大学,中医药学院,研究助理教授

2008/10–2011/11    美国南佛罗里达大学,Moffitt(莫菲特)癌症中心,博士后

2007/04–2008/10    香港浸会大学,中医药学院,博士后


交叉研究领域   

结合生物化学,药物化学,分子生物学和化学生物学领域, 从事跨学科研究. 研究领域包括: 结合光动力学疗法和靶向治疗的新型抗耐药肿瘤药物研究、基于过渡金属配合物的生物荧光探针应用研究、新型金属抗癌药物的合成和生物评估研究。

 

代表文章

1. Tse AK#, Chen YJ, Fu XQ, Su T, Li T, Guo H, Zhu PL, Kwan HY, Cheng BC, Cao HH, Lee SK, Fong WF, Yu ZL#. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biology 2017 Jan 12;11:562-576. (#Corresponding authors)

2. Wu J, Du J, Fu X, Liu B, Cao H, Li T, Su T, Xu J, Tse AK#, Yu ZL#. Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling. Oncotarget 2016 Aug 9;7(32):51251-51269. (# Corresponding authors)

3. Tse AK, Cao HH, Cheng CY, Kwan HY, Yu H, Fong WF, Yu ZL. Indomethacin Sensitizes TRAIL-Resistant Melanoma cells to TRAIL-induced Apoptosis through ROS-mediated Up-regulation of Death Receptor 5 and Down-regulation of Survivin. Journal of Investigative Dermatology, 2014 May;134(5):1397-407.

Featured in Journal of Investigative Dermatology Commentary (2014): “Indomethacin to the rescue of TRAIL-resistant melanomas” Somasundaram R, Herlyn M. J Invest Dermatol. 2014 May;134(5):1198-9. http://www.nature.com/jid/journal/v134/n5/full/jid20141a.html

4. Tse AK, Chow KY, Cao HH, Cheng CY, Kwan HY, Yu H, Zhu GY, Wu YC, Fong WF, Yu ZL. The Herbal Compound Cryptotanshinone Restores Sensitivity in Cancer Cells that are Resistant to the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. The Journal of Biological Chemistry 2013 Oct 11;288(41):29923-29933.

5. Tse AK *,Yang Y*, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene 2011 May 12;30(19):2207-18. (* Co-first author)

6. Tse AK, Zhu GY, Wan CK, Shen XL, Yu ZL, Fong WF. 1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells. Molecular Immunology 2010 May;47(9):1728-38.

7. Tse AK, Wan CK, Shen XL, Zhu GY, Cheung HY, Yang M, Fong WF. 1,25-Dihydroxyvitamin D(3) induces biphasic NF-kappaB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IkappaB. Experimental Cell Research 2007 May 1;313(8):1722-34.

8. Tse AK, Wan CK, Zhu GY, Shen XL, Cheung HY, Yang M, Fong WF.  Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation. Molecular Immunology 2007 Apr;44(10):2647-58.

9. Tse AK, Wan CK, Shen XL, Yang M, Fong WF. Honokiol Inhibits TNF-α-Stimulated NF-κB Activation and NF-κB-Regulated Gene Expression Through Suppression of IKK Activation.  Biochemical Pharmacology 2005 Nov 15;70(10):1443-1457.


联系方式

xieqr@sustc.edu.cn