生物医药研究院

温佳琳

生物医药研究院

研究助理教授

wenjl@sustc.edu.cn


教育经历

2011-2016,罗格斯新泽西州立大学,博士

2007-2011,南京大学,理学学士


工作经历

2017-,南方科技大学,前沿与交叉科学研究院,研究助理教授;

2016-2017,南方科技大学,博士后


交叉研究领域

利用氢键和库仑力等非共价作用,将催化剂分子和底物结合在一起,降低催化口袋局部Gibbs自由能,从而达到促进反应的作用。应用这一策略,有挑战性的氢化底物可以实现温和条件下的催化加氢。这一反应模式可以用于手性小分子的高效构建,也可以应用于二氧化碳的还原,实现氢能的存储。


所获荣誉

深圳市海外高层次“C类”人才(孔雀计划C类)


代表文章

1. Jialin Wen, ... Lung Wa Chung, Xumu Zhang. Brønsted acid promoted Rh-catalyzed asymmetric hydrogenation of N-unprotected indoles: a co-catalysis of transition metal and anion binding. Org. Lett. ASAP.2. Guoxian Gu, ..., Jialin Wen,* Li Dang* and Xumu Zhang*. Iridium/f-ampha-catalyzed asymmetric hydrogenation of aromatic α-keto esters. Org. Chem. Front. DOI: 10.1039/c8qo00047f.

2. Guoxian Gu,... Jialin Wen, Li Dang, and Xumu Zhang. Enantioselective Iridium-Catalyzed Hydrogenation of αKeto Amides to αHydroxy Amides. Org. Lett. 2017, 19, 5920.

3. Jean-Nicolas Desrosiers*, Jialin Wen, Sergei Tcyrulnikov, … Xumu Zhang, Marisa C. Kozlowski,* Chris H. Senanayake. Enantioselective Nickel-Catalyzed Heck Cyclization to Generate Quaternary Stereocenters. Org. Lett. 2017, 19, 3338-3341.

4. Jialin Wen, Jun Jiang, Xumu Zhang*. Rhodium-Catalyzed Asymmetric hydrogenation of α, β-unsaturated carbonyl compounds via thiourea hydrogen bonding. Org. Lett. 2016, 18, 4451–4453.

5. Jialin Wen, Renchang Tan, Shaodong Liu, Qingyang Zhao, Xumu Zhang*. Strong Brønsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh-thiourea chiral phosphine complex via ainon binding. Chem. Sci. 2016, 7, 3047-3051.

6. Lin Yao, Jialin Wen, Shaodong Liu, Renchang Tan, Neol M. Wood, Weiping Chen, Shengyong Zhang, Xumu Zhang*. Highly enantioselective hydrogenation of α–oxy functionalized α, β-unsaturated acids catalyzed by a ChenPhos–Rh complex in CF3CH2OH. Chem. Comm. 2016, 52, 2273-2276.

7. Qingyang Zhao, Jialin Wen, Renchang Tan, Kexuan Huang, Pedro Metola, Rui Wang, Eric V. Anslyn*, Xumu Zhang*, Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea. Angew. Chem. Int. Ed. 2014, 53, 8467.

 

联系方式

wenjl@sustc.edu.cn

0755-88108339