生物医药研究院

向少华

生物医药研究院

研究助理教授

xiangsh@sustc.edu.cn


教育经历

2015       南洋理工大学(新加坡) 博士

2009       厦门大学 硕士

2006       厦门大学 学士


工作经历

2017-今        南方科技大学前沿与交叉科学研究院 研究助理教授

2015-2017   深圳华大基因研究院 产品经理


交叉研究领域

将有机小分子催化与糖化学相结合发展更加高效的糖苷化策略,在传统医药分子中引入糖分子开发活性更高的新型药物分子。


所获荣誉

深圳市海外高层次“C类”人才(孔雀计划C类)


代表文章

1.  Xiang, S.; Hoang, K. L. M.; He, J.; Tan, Y.; Liu, X.-W.* Reversing the Stereoselectivity of a Palladium-Catalyzed O-Glycosylation through an Inner-Sphere or Outer-Sphere Pathway. Angew. Chem. Int. Ed. 2015, 54, 604.

2.  Ma, J.; Xiang, S.; Jiang, H.; Liu, X.-W.* Palladium-Catalyzed Stereoselective C-Glycosylation of Glycals with Sodium Arylsulfinate. Eur. J. Org. Chem. 2015, 949. (†Equal contribution).

3.  Ji, L.; Xiang, S.; Leng, W. L.; Hoang, K. L. M.; Liu, X.-W.* Palladium Catalyzed Glycosylation: Novel Synthetic Approach to Diverse N-Heterocyclic Glycosides. Org. Lett. 2015, 17, 1357. (†Equal contribution).

4. Xiang, S.; He, J.; Tan, Y.; Liu, X.-W.* Stereo-Controlled O-Glycosylation with Palladium-Catalyzed Decarboxylative Allylation. J. Org. Chem. 2014, 79, 11473.

5. Xiang, S.; He, J.; Ma, J.; Liu, X.-W.* One-pot Synthesis of b-N-Glycosyl Imidazole Analogues via a Palladium-Catalysed Decarboxylative Allylation. Chem. Commun. 2014, 50, 4222.

6. Xiang, S.; Lu, Z.; He, J.; Hoang, K. L. M.; Zeng, J.; Liu, X.-W.* b-Type Glycosidic Bond Formation by Palladium-Catalyzed Decarboxylative Allylation. Chem. Eur. J. 2013, 19, 14047.

7. Xiang, S.; Cai, S. T.; Zeng, J.; Liu, X.-W.* Regio- and Stereoselective Synthesis of 2-Deoxy-C-aryl Glycosides via Palladium Catalyzed Decarboxylative Reactions. Org. Lett. 2011, 13, 4608.

8. Xiang, S.; Ma, J.; Gorityala, B. K.; Liu, X.-W.*  Stereoselective synthesis of b-N-glycosides through 2-deoxy-2-nitroglycal. Carbohydr. Res. 2011, 346, 2957.

9. Xiang, S.; Xu, J.; Yuan, H.; Huang, P.-Q.* Reduction of Amides to Amines by NaBH4 under Mild Conditions. Synlett 2010, 20, 1829.

10. Xiang, S.; Yuan, H.; Huang, P.-Q.* A Versatile Approach to cis-5-Substituted 4-Hydroxy-2-Pyrrolidinones: Asymmetric Synthesis of Angiogenesis Inhibitor Streptopyrrolidine. Tetrahedron: Asymmetry 2009, 20, 2021.


联系方式

xiangsh@sustc.edu.cn

13927406581